Long-Term Melatonin Use Linked to Increased Heart Risks
A recent preliminary study presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans indicates that long-term melatonin use may significantly raise the risk of heart failure, hospitalization, and death.
About Melatonin
Melatonin is a hormone naturally produced by the pineal gland that regulates the body's sleep-wake cycle. Its levels rise in darkness and fall during daylight. Synthetic versions, chemically identical to the natural hormone, are commonly used to treat insomnia and jet lag and are widely available over the counter in many countries.
Study Design and Groups
Researchers categorized participants based on melatonin use documented in their electronic health records. Those who had used melatonin for a year or more formed the “melatonin group,” while individuals with no record of melatonin use were placed in the “non-melatonin group.”
“Long-term use of melatonin, a supplement primarily used to manage sleep disorders by regulating the body's internal clock, may be associated with a significantly higher risk of heart failure, hospitalization, and death.”
Key Findings
- Use of melatonin for one year or longer correlates with increased risk of heart-related hospitalization and mortality.
- Melatonin's role in sleep regulation is well-established, but potential cardiovascular risks warrant caution.
Implications
This study suggests that prolonged melatonin supplementation, although helpful for sleep issues, might carry serious cardiovascular risks, highlighting the need for further investigation and medical consultation before extended use.
Author’s summary: Prolonged melatonin use, commonly considered safe for sleep disorders, may pose increased heart failure and mortality risks, urging cautious long-term consumption and further research.