Helen Mirren plays the role of Patricia Highsmith in the upcoming film A Talent for Murder, under the direction of Anton Corbijn. Critics have described her performance as sharp and edgy. Mirren has stated Highsmith the most difficult real person she has ever taken on, highlighting her rough character.

Both Mirren and Brosnan defended the actor Tom Hardy following gossip about issues on the set of the television series MobLand. Mirren talked about the part at TIFF.